What is hyaluronic acid and what effect does it have on the dry eye?

Hyaluronic acid is a natural component that is part of the human body. Among the various organs and fluids where it is located, there is the tear.

Thanks to the high binding capacity of hyaluronic acid with water and the high physical-chemical similarity with the glycoproteins of the corneal mucosal layer, it has an excellent ability to bond to the ocular surface, performing the following actions on the eye in case of suffering from Dry Eye:

  • Decrease in tear exchange rate.

  • Improvement of the corneal epithelium.

  • Improves the stability of the lacrimal layer.

 Not all hyaluronic acids are the same 
 molecular weight matters 

Hylo hyaluronic acid is obtained from biotechnological synthesis and it is filtered and purified to select only long chains of hyaluronic acid, with a molecular weight between 1.5 and 3.5 million Daltons.

  • And, why do we only want long chains of hyaluronic acid?

    The answer is that with a high molecular weight, the moisturizing and lubricating effect of hyaluronic acid is more intense and more durable than short-chain hyaluronic acids.


  • Why does molecular weight matter?

    Because the hydration capacity = molecular weight (Da) x viscosity * (mm2 / s) hyaluronic acid concentration (%) x

    * Molecular weight has a critical effect on viscosity

Another important feature is the concentration of hyaluronic acid. Ophthalmic drops with high concentrations of hyaluronic acid are available on the market. However, it has been shown that high concentrations do not provide greater hydration and cause blurred vision to the patient.

HYLO® tears have a concentration of 0.10% in their HYLO-COMOD® presentation and 0.20% in HYLO-GEL®. With these concentrations we achieve a high hydration of the ocular surface without blurred vision.